Oprensning af fluormethyl-1,1,1,3,3,3-hexafluorisopropylether (sevofluran)

Crude sevoflurane product comprising unacceptably high levels of HFIP can be purified by combining the crude sevoflurane product with sufficient water to produce a multiphase mixture, fractionally distilling the multiphase mixture, removing sevoflurane from the distilling multiphase mixture as an az...

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Bibliographische Detailangaben
Hauptverfasser: JONES, BARRY, SWINSON, JOEL
Format: Patent
Sprache:dan
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Zusammenfassung:Crude sevoflurane product comprising unacceptably high levels of HFIP can be purified by combining the crude sevoflurane product with sufficient water to produce a multiphase mixture, fractionally distilling the multiphase mixture, removing sevoflurane from the distilling multiphase mixture as an azeotrope with water, and separating substantially pure sevoflurane from the azeotrope.