KROMATOGRAFIMATRIX

The present invention relates to a chromatography ligand defined by the following formula R1-R2-N(R3)-R4-R5 wherein R1 is a substituted or non-substituted phenyl group; R2 is a hydrocarbon chain comprising 0-4 carbon atoms; R3 is a hydrocarbon chain comprising 1-3 carbon atoms; R4 is a hydrocarbon c...

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Bibliographische Detailangaben
Hauptverfasser:	MALOISEL, Jean-Luc, Amersham Biosciences Ab, ENGSTRAND, Carina, Amersham Biosciences AB, FORSS, Annika, Amersham Biosciences AB, GLAD, Gunnar, Amersham Biosciences AB, JOHANSSON, Bo-Lennart, Amersham Biosciences AB, JOHANSSON, Hans J., Amersham Biosciences AB
Format:	Patent
Sprache:	dan
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SEPARATION THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	The present invention relates to a chromatography ligand defined by the following formula R1-R2-N(R3)-R4-R5 wherein R1 is a substituted or non-substituted phenyl group; R2 is a hydrocarbon chain comprising 0-4 carbon atoms; R3 is a hydrocarbon chain comprising 1-3 carbon atoms; R4 is a hydrocarbon chain comprising 1-5 carbon atoms; and R5 is OH or H. The invention also comprises a separation matrix, comprising the described ligands coupled to a porous support, such as particles or a membrane. The ligand and matrix according to the invention is useful for purification of biomolecules or organic compounds, such as proteins, polypeptides, DNA etc. An advantageous use according to the invention is the purification of antibodies.