5-Substituerede 2-phenylamino-benzamider som MEK-inhibitorer

An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically accepta...

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Hauptverfasser:	MATSUBARA, YASUAKI, SHIMMA, NOBUO, MIWA, MASANORI, TSUJII, SHINJI, AIDA, SATOSHI, KOHCHI, YASUNORI, KOHCHI, MASAMI, MIZUGUCHI, EISAKU, ISSHIKI, YOSHIAKI, IIKURA, HITOSHI, MURATA, TAKESHI, ASO, KOSUKE
Format:	Patent
Sprache:	dan
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1): [where R 1 , R 2 , R 3 , R 4 , and X are the same as defined in the present patent application].