OPTISK AKTIVE ELLER RACEMISKE 13-THIA-PROSTACYCLINDERIVATER,DERES FREMSTILLING OG ANVENDELSE SOM FARMACEUTIKA

OPTISK AKTIVE ELLER RACEMISKE 13-THIA-PROSTACYCLINDERIVATER,DERES FREMSTILLING OG ANVENDELSE SOM FARMACEUTIKA

The invention relates to new optically active or racemic 13-thia-prostacycline derivatives of the Formula I I. wherein R1 is hydrogen, a pharmaceutically acceptable cation or a straight or branched chain alkyl group having 1-5 carbon atoms; R2 is straight or branched chain alkyl having 4-9 carbon at...

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Bibliographische Detailangaben
Hauptverfasser: SSZANTAY C, NOVAK L, STADLER I, KOVACS G, KOERMOECZY P, GALAMBOS G, VIRAG S, SIMONIDESZ V
Format: Patent
Sprache:dan
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to new optically active or racemic 13-thia-prostacycline derivatives of the Formula I I. wherein R1 is hydrogen, a pharmaceutically acceptable cation or a straight or branched chain alkyl group having 1-5 carbon atoms; R2 is straight or branched chain alkyl having 4-9 carbon atoms or monosubstituted phenoxymethyl; -A-B- is -CH2-CH2-, -CH=CH- of Z- or E- configuration or -C 3BOND C-; one of the symbols X and Y is hydrogen, methyl or ethyl and the other is hydroxy, tetrahydropyranyoxy, 1-ethoxy-ethoxy or trialkylsilyloxy; or X and Y together form a -O-CH2-CH2-O- group; Z is a sulfur atom or a -SO- group. The compounds of the Formula I can be prepared by reacting a 13-thia-prostaglandine of the Formula III III.