Alfa, alfa-diaryl-4-aryl-4-hydroxy-1-piperidinbutanamid, N-oxider, fremgangsmåde til fremstilling heraf og præparater indeholdende forbindelserne

Novel alpha , alpha -diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, N-oxides of formula wherein R is hydrogen or methyl; Ar and Ar are, each independently, phenyl or halophenyl; Alk is -CH2-CH2- or -CH2-CH(CH3)-; R and R are, each independently, hydrogen, C1-6alkyl, phenylmethyl or 2-propenyl or R and R combined with the nitrogen atom bearing said R and R may form a pyrrolidinyl, piperidinyl, C1-6alkylpipridinyl, 4-morpholinyl or 2,6-di(C1-6alkyl)-4-morpholinyl radical; Ar is phenyl being optionally substituted with up to 3 substituents selected from the group consisting of C1-6alkyl, C1-6alkyloxy, halo and trifluoromethyl; the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-diarrheal agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.