TEMPLATE-FIKSEREDE BETA-HAIRPINLOOPMIMETIKA OG DERES ANVENDELSE I FAG-DISPLAY

A method of screening for template-fixed -hairpin mimetics and libraries including a plurality of these mimetics is provided. The template-fixed -hairpin mimetics are of the following general formula: R1-Cys-Z-Cys-R2 I wherein the two cysteine residues are bridged by a disulfide bond, thereby formi...

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Bibliographische Detailangaben
Hauptverfasser:	GOMBERT, FRANK, OTTO, OBRECHT, DANIEL, VRIJBLOED, JAN, WIM, LOCURIO, SERGIO, JUNG, FRANÇOISE, LUDIN, CHRISTIAN
Format:	Patent
Sprache:	dan
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A method of screening for template-fixed -hairpin mimetics and libraries including a plurality of these mimetics is provided. The template-fixed -hairpin mimetics are of the following general formula: R1-Cys-Z-Cys-R2 I wherein the two cysteine residues are bridged by a disulfide bond, thereby forming a cyclic peptide; R1 and R2 are di- or tripeptide moieties of certain types, as defined herein; and Z is a chain of n amino acid residues with n being an integer from 4 to 20 and with each of these n amino acid residues being, independently, derived from any naturally occurring L-α-amino acid.