FREMGANGSMAADE TIL FREMSTILLING AF KRYSTALLINSK CEFUROXIMAXETIL SAMT DENNE FORBINDELSE PAA HOEJREN FORM

FREMGANGSMAADE TIL FREMSTILLING AF KRYSTALLINSK CEFUROXIMAXETIL SAMT DENNE FORBINDELSE PAA HOEJREN FORM

A process for obtaining highly pure crystalline cefuroxime axetil comprises crystallising cefuroxime axetil from a solution thereof in an organic or aqueous solvent or a mixture thereof and then drying and isolating the product. Preferred solvents are alkyl acetates in admixture with ethers or aliph...

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Bibliographische Detailangaben
Hauptverfasser: CRISP, HAROLD ALFRED, TURNBULL, JOHN PETER, WRIGHT, MICHAEL, JOHN FRANCIS OUGHTON
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:A process for obtaining highly pure crystalline cefuroxime axetil comprises crystallising cefuroxime axetil from a solution thereof in an organic or aqueous solvent or a mixture thereof and then drying and isolating the product. Preferred solvents are alkyl acetates in admixture with ethers or aliphatic or aromatic hydrocarbons. The higher the yield from crystallisation, the closer to a 1:1 stoichiometric ratio of R:S isomers the product will contain, this being most desirable for an antibiotic product which is to be administered orally.