17BETA-N-MONOSUBSTITUEREDE CARBAMOYL-4-AZA-5ALFA-ANDROST-1-EN-3-ON-FORBINDELSER OG PRAEPARATER INDEHOLDENDE DISSE FORBINDELSER

17BETA-N-MONOSUBSTITUEREDE CARBAMOYL-4-AZA-5ALFA-ANDROST-1-EN-3-ON-FORBINDELSER OG PRAEPARATER INDEHOLDENDE DISSE FORBINDELSER

The compounds of formula (I) wherein R is selected from hydrogen, methyl or ethyl, and R is C1-12 straight or branched chain alkyl wherein one of the hydrogens is substituted by hydroxy, carboxylic acid or C1-4 alkyl ester, and A is -CH2-CH2 or -CH=CH-, and pharmaceutical formulations of the above c...

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Bibliographische Detailangaben
Hauptverfasser: RASMUSSON, GARY H, CARLIN, JOSEPHINE R, VANDENHEUVEL, W.J.A
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Zusammenfassung:The compounds of formula (I) wherein R is selected from hydrogen, methyl or ethyl, and R is C1-12 straight or branched chain alkyl wherein one of the hydrogens is substituted by hydroxy, carboxylic acid or C1-4 alkyl ester, and A is -CH2-CH2 or -CH=CH-, and pharmaceutical formulations of the above compounds are active as testosterone 5 alpha -reductase inhibitors and thus are useful for treatment of acne, seborrhea, female hirsutism or benign prostatic hypertrophy.