Reduktion af udvaskning af protein A under protein A-affinitetskromatografi

A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature of pH of, or by adding one or more protease inhibitors to, a composition that is subject to protein A affinity chromatography.

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Bibliographische Detailangaben
Hauptverfasser: FAHRNER, Robert L, O'LEARY, Rhona M, LAVERDIERE, Amy, McDONALD, Paul J
Format: Patent
Sprache:dan
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Zusammenfassung:A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature of pH of, or by adding one or more protease inhibitors to, a composition that is subject to protein A affinity chromatography.