N-PIPERAZINYLALKANOYLANILIDER OG FARMACEUTISKE KOMPOSITIONER, DER INDEHOLDER DISSE FORBINDELSER

N-PIPERAZINYLALKANOYLANILIDER OG FARMACEUTISKE KOMPOSITIONER, DER INDEHOLDER DISSE FORBINDELSER

N-piperazinylalkanoylanilides of formulawherein is O, 1 or2, each of Rand R, is H or alkyl, and each of R2, R3 and R4 is H, halogen, alkyl, hydroxy-alkyl, alkoxy, aralkoxy, alkylthio, aralkylthio, alkylsulphonyl, alkylsulphenyl, NO2, NH2, alkylamino, acylamino, ureido, alkylureido, alkylsulphonylami...

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Hauptverfasser: CATTO, ALBERTO, NARDI, DANTE, GRAZIANI, GABRIELE, LEONARDI, AMEDEO
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:N-piperazinylalkanoylanilides of formulawherein is O, 1 or2, each of Rand R, is H or alkyl, and each of R2, R3 and R4 is H, halogen, alkyl, hydroxy-alkyl, alkoxy, aralkoxy, alkylthio, aralkylthio, alkylsulphonyl, alkylsulphenyl, NO2, NH2, alkylamino, acylamino, ureido, alkylureido, alkylsulphonylamino, CF3, acyl, CN, COOH, alkoxycarbonyl, NH2CO, SO3H, guanidinosulphonyl, NH2COO, OH, acyloxy, alkylsulphonyloxy, alkylenedioxy or SO2NR5R6 wherein each of R5 and R6 is H, alkyl, aryl or acyl, and their pharmaceutically acceptable acid addition salts, are antihypertensive agents.They may be prepared by condensing 1-(2-methoxyphenyl)- -piperazine with an alkanoylanilide of formula