FREMGANGSMAADE TIL FREMSTILLING AF BETA-LACTAM-ANTIBIOTICA

A procedure for preparing derivatives of b-bactamic antibiotics. Consists of the following stages: 1) submit a reaction to a compound (II) with r and in a halogenated aliphatic hidrocarbon solvent. 2) react the compound obtained with zinc and a selected acid from between inorganic acids, monosteres...

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Hauptverfasser: NAKAZAWA, JUNICHI, MIYAOKA, TAKEO, KANEKO, MASANAO
Format: Patent
Sprache:dan
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Zusammenfassung:A procedure for preparing derivatives of b-bactamic antibiotics. Consists of the following stages: 1) submit a reaction to a compound (II) with r and in a halogenated aliphatic hidrocarbon solvent. 2) react the compound obtained with zinc and a selected acid from between inorganic acids, monosteres of dibasic inorganic acids and sulphonic acids, in an inert solvent. 3) if necessary, the compound obtained (I) is solelized to give the corresponding salt pharmaceutically acceptable. R is a group acil; r is an atom of hydrogen or a metoxy group; r is a group aminodinotio or a group heterocicliltio; x is sulfur, oxygen or a methylene group. (Machine-translation by Google Translate, not legally binding)