FREMGANGSMAADE TIL 5-AROYLERING AF 1,2-DIHYDRO-3H-PYRROLOOE1,2-AAAPYRROL-1-NITRILER

FREMGANGSMAADE TIL 5-AROYLERING AF 1,2-DIHYDRO-3H-PYRROLOOE1,2-AAAPYRROL-1-NITRILER

A process for 5-aroylation of 1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole-1-carboxylic esters and nitriles by reacting a pyrrolo pyrrole with an aroyl morpholide and an inorganic acid chloride in an inert aprotic solvent; followed by treatment with weak or strong base to form: The nitrile (V) can be hydro...

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Bibliographische Detailangaben
Hauptverfasser: TEGG, DEREK, THURBER, TIMOTHY C
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:A process for 5-aroylation of 1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole-1-carboxylic esters and nitriles by reacting a pyrrolo pyrrole with an aroyl morpholide and an inorganic acid chloride in an inert aprotic solvent; followed by treatment with weak or strong base to form: The nitrile (V) can be hydrolyzed to the acid (III).