Indazolforbindelser og farmaceutiske sammensætninger til inhibering af proteinkinaser og fremgangsmåder til deres anvendelse

Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The inv...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	LUU, HIEP THE, HUA, YE, KANIA, ROBERT STEVEN, BENDER, STEVEN LEE, REICH, SIEGFRIED HEINZ, CRIPPS, STEPHAN JAMES, BRAGANZA, JOHN F, JOHNSON, THEODORE OTTO JR, VARNEY, MICHAEL DAVID, PALMER, CYNTHIA LOUISE, THOMAS, CHRISTINE, COLLINS, MICHAEL RAYMOND, TENG, MIN, WALLACE, MICHAEL BRENNAN, JOHNSON, MICHAEL DAVID, TEMPCZYK-RUSSELL, ANNA MARIA, BORCHARDT, ALLEN J
Format:	Patent
Sprache:	dan
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.