ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF ET DERIVAT AF ET IN-VIVO-FIBRINOLYTISK ENZYM

A pharmaceutical composition which comprises a pharmaceutically acceptable carrier together with an in vivo fibrinolytic enzyme as defined herein wherein the catalytic site essential for fibrinolytic activity is blocked by a group which is removable by hydrolysis at a rate such that the pseudo-first...

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Bibliographische Detailangaben
1. Verfasser: SMITH, RICHARD ANTHONY GODWIN
Format: Patent
Sprache:dan
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Zusammenfassung:A pharmaceutical composition which comprises a pharmaceutically acceptable carrier together with an in vivo fibrinolytic enzyme as defined herein wherein the catalytic site essential for fibrinolytic activity is blocked by a group which is removable by hydrolysis at a rate such that the pseudo-first order rate constant for hydrolysis is in the range 10-6 sec-1 to 10-3sec-1 in isotonic aqueous media at pH 7.4 at 37°C; is useful in the treatment of venous thrombosis.