FREMGANGSMAADE TIL FREMSTILLING AF 4-METYL-5-ALKYLTHIOMETYL-IMIDAZOLER

A new process is described for the production of 4-methyl-5-substituted- alkylthiomethyl-imidazoles, particularly Cimetidine of the formula by the following series of reactions wherein Alk is alkylene preferably -CH2-CH2- and Alk is C1-4 alkyl preferably CH3. The reactions for the selective reductio...

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Hauptverfasser:	CLAUSEN, FINN PRIESS, GELTING, NIELS, ALHEDE, BOERGE, PREIKSCHAT, HERBERT
Format:	Patent
Sprache:	dan
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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creator	CLAUSEN, FINN PRIESS GELTING, NIELS ALHEDE, BOERGE PREIKSCHAT, HERBERT
description	A new process is described for the production of 4-methyl-5-substituted- alkylthiomethyl-imidazoles, particularly Cimetidine of the formula by the following series of reactions wherein Alk is alkylene preferably -CH2-CH2- and Alk is C1-4 alkyl preferably CH3. The reactions for the selective reduction of Y and the deoxygenation may be effected in reverse order. The starting compound may have a second oxime group replacing the keto group or the oxime and keto groups shown may be transposed. The thioether cyanoguandines produced in the first reaction step are claimed as new compounds.
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The reactions for the selective reduction of Y and the deoxygenation may be effected in reverse order. The starting compound may have a second oxime group replacing the keto group or the oxime and keto groups shown may be transposed. 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subjects	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
title	FREMGANGSMAADE TIL FREMSTILLING AF 4-METYL-5-ALKYLTHIOMETYL-IMIDAZOLER
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