FREMGANGSMAADE TIL FREMSTILLING AF 4-METYL-5-ALKYLTHIOMETYL-IMIDAZOLER

FREMGANGSMAADE TIL FREMSTILLING AF 4-METYL-5-ALKYLTHIOMETYL-IMIDAZOLER

A new process is described for the production of 4-methyl-5-substituted- alkylthiomethyl-imidazoles, particularly Cimetidine of the formula by the following series of reactions wherein Alk is alkylene preferably -CH2-CH2- and Alk is C1-4 alkyl preferably CH3. The reactions for the selective reductio...

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Bibliographische Detailangaben
Hauptverfasser: CLAUSEN, FINN PRIESS, GELTING, NIELS, ALHEDE, BOERGE, PREIKSCHAT, HERBERT
Format: Patent
Sprache:dan
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A new process is described for the production of 4-methyl-5-substituted- alkylthiomethyl-imidazoles, particularly Cimetidine of the formula by the following series of reactions wherein Alk is alkylene preferably -CH2-CH2- and Alk is C1-4 alkyl preferably CH3. The reactions for the selective reduction of Y and the deoxygenation may be effected in reverse order. The starting compound may have a second oxime group replacing the keto group or the oxime and keto groups shown may be transposed. The thioether cyanoguandines produced in the first reaction step are claimed as new compounds.