ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF INDOLDERIVATER

Compounds are disclosed of general formula (I> wherein R1 represents a group CHO, COR8, CO2R8, CONR9R10, CSNR9R10 or SO2NR9R10, where R8 represents an alkyl, cycloalkyl, aryl or aralkyl group, R9 represents a hydrogen atom or an alkyl group, and R10 represents a hydrogen atom or an alkyl, cycloalkyl, aryl or aralkyl group; R2, R3, R4, R6 and R7, which may be the same or different, each represents a hydrogen atom or a C1-3 alkyl group; R5 represents a hydrogen atom or an alkyl, cycloalkyl, alkenyl or an aralkyl group or R4 and R5 together form an aralkylidene group or R4 and R5 together with the nitrogen atom to which they are attached form a saturated monocyclic 5- to 7-membered ring; n is zero or 1; and Alk represents an alkylene chain containing two or three carbon atoms which may be unsubstituted or substituted by not more than two C1-3 alkyl groups; with the provisos that, when n is zero and (i) R4 and R5, both represent alkyl groups, R1 does not represent the group CHO or COR8; and (ii) R1 does not represent the group SO2NH2; and physiologically acceptable salts, solvates and bioprecursors thereof. The compounds are described as potentially useful for the treatment of migraine.