ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF HETEROCYCLISKE AMIDER AF 4-HYDROXY-2H-1-BENZOTHIOPYRAN-3-CARBOXYLSYRE-1,1-DIOXID

1365849 Substituted 4-hydroxy-1-benzothiopyran-3-carboxamide-1,1-dioxides WARNERLAMBERT CO 4 April 1973 [28 April 1972] 16043/73 Heading C2C Novel benzothiopyran - 3 - carboxamides of Formula I wherein R 1 is an optionally substituted heterocyclic aromatic radical, R 2 is H or halogen or an alkyl, aryl, aralkyl, alkoxy, cyano, nitro or trifluoromethyl radical, and the salts thereof may be prepared by reacting a compound of Formula II in which R 2 is as above and R 3 is an alkyl or aryl radical with a compound of formula in which R 1 is as defined above. In exemplified compounds R 2 is hydrogen and R 1 is 2-pyridyl, 4-, 5- & 6-methyl-2-pyridyl, 5- chloro-2-pyridyl, 5-nitro-2-pyridyl, 2-thiazolyl and 5-methyl-3-isoxazolyl. Pharmaceutical compositions having antiinflammatory activity for oral, injection or parenteral administration comprise at least one compound of Formula I together with a solid or liquid pharmaceutical diluent or carrier.