7-BROM-1,2-METHYLEN-5-(2-HALOGENPHENYL)-1H-2,3-DIHYDRO-1,4-BENZODIAZEPINER OG FREMGANGSMAADE TIL FREMSTILLING AF 7-BROM-5-(2-HALOGENPHENYL)-1H-2,3-DIHYDRO-1,4-BENZODIAZEPIN-FORBINDELSER ELLER SYREADDITIONSSALTE DERAF

7-BROM-1,2-METHYLEN-5-(2-HALOGENPHENYL)-1H-2,3-DIHYDRO-1,4-BENZODIAZEPINER OG FREMGANGSMAADE TIL FREMSTILLING AF 7-BROM-5-(2-HALOGENPHENYL)-1H-2,3-DIHYDRO-1,4-BENZODIAZEPIN-FORBINDELSER ELLER SYREADDITIONSSALTE DERAF

Disclosed are 7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines of the formula I I in which R1 is a hydrogen atom or a lower alkoxy or alkanoyloxy radical and R2 is a halogen atom. The compounds possess psychopharmacological, and especially anti-aggressive properties. To manufacture compou...

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Bibliographische Detailangaben
Hauptverfasser: ZEUGNER, HORST, RUHLAND, MICHAEL, MUESCH, HERBERT, MILKOWSKI, WOLFGANG, LIEPMANN, HANS
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Disclosed are 7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines of the formula I I in which R1 is a hydrogen atom or a lower alkoxy or alkanoyloxy radical and R2 is a halogen atom. The compounds possess psychopharmacological, and especially anti-aggressive properties. To manufacture compounds of formula I, corresponding 2-halomethyl-7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines are cyclized to corresponding 7-bromo-1,2-methylene-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines and in these the aziridine ring is opened through treatment with a lower alcohol or a lower carboxylic acid in the presence of a Lewis acid.