ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF N-(3-ACYLTHIO-2-METHYLPROPANOYL)-PROLINFORBINDELSER ELLER SALTE HERAF

ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF N-(3-ACYLTHIO-2-METHYLPROPANOYL)-PROLINFORBINDELSER ELLER SALTE HERAF

Proline derivatives of the formula (I): (wherein R is an acyl group bonded to the alpha -amino group of amino acid A and is selected from the group consisting of cyclopropanecarbonyl, cyclohexanecarbonyl and adamantanecarbonyl groups; A is glycine, sarcosine or alpha -D-amino acid residue the carbon...

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Hauptverfasser: TANAKA, SADAO, AONO, JUNICHIRO, HATA, SHUN-ICHI, MATSUNAGA, ISAO, FUKUSHIMA, MASAFUMI, SAKAI, KAZUSHIGE, KUROMARU, KIYONORI, OBATAKE, NORIKO, IWAOKA, TOMOYASU, NABATA, HIROYUKI, NAKANO, HIDEKI, HINOHARA, YOSHIKAZU, FUJIMURA, YASUO
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
CONVEYING
HANDLING THIN OR FILAMENTARY MATERIAL
HANDLING THIN OR FILAMENTARY MATERIAL, e.g. SHEETS, WEBS,CABLES
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PACKING
PERFORMING OPERATIONS
STORING
TRANSPORTING
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Zusammenfassung:Proline derivatives of the formula (I): (wherein R is an acyl group bonded to the alpha -amino group of amino acid A and is selected from the group consisting of cyclopropanecarbonyl, cyclohexanecarbonyl and adamantanecarbonyl groups; A is glycine, sarcosine or alpha -D-amino acid residue the carbonyl group of which forms a thiol ester bond with the sulfur atom) or a pharmaceutically acceptable salt thereof, and a process for producing the same are disclosed. The proline derivatives are useful for treating hypertension due to angiotensin II, and as an agent to treat cardiac insufficiency.