FREMGANGSMÅDE TIL HUMANISERING AF IMMUNSYSTEMSMOLEKYLER

Disclosed are methods for making immune system molecules, particularly humanized antibodies and fragments thereof. A typical method optimizes similarity between individual antibody framework regions to help identify human framework regions suitable for making the molecules. Comparisons between large...

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Bibliographische Detailangaben
Hauptverfasser:	MOSQUERA, LUIS A, STINSON, JEFFREY R, WONG, HING C
Format:	Patent
Sprache:	dan
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed are methods for making immune system molecules, particularly humanized antibodies and fragments thereof. A typical method optimizes similarity between individual antibody framework regions to help identify human framework regions suitable for making the molecules. Comparisons between larger antibody frameworks, hypervariable domains or both is avoided. Also disclosed are antibodies that have been humanized by the method. The invention has a wide spectrum of applications including use in the production of humanized monoclonal antibodies with suitable binding affinity and minimized human immunogenicity.