FREMGANGSMAADE TIL FREMSTILLING AF 7-ACYLAMIDO-CEPHALOSPORIN-FORBINDELSER

FREMGANGSMAADE TIL FREMSTILLING AF 7-ACYLAMIDO-CEPHALOSPORIN-FORBINDELSER

Cephem derivatives of the following formula in which the substituents are defined in Claim 1, are prepared by a novel process. In this process, an appropriate 7-acylamidocephem derivative having a protected carboxyl group in the 4-position is reacted in the presence of a molecular sieve with an acyl...

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Bibliographische Detailangaben
1. Verfasser: WEINSTOCK, LEONARD MAURICE
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Cephem derivatives of the following formula in which the substituents are defined in Claim 1, are prepared by a novel process. In this process, an appropriate 7-acylamidocephem derivative having a protected carboxyl group in the 4-position is reacted in the presence of a molecular sieve with an acylating agent donating the desired acyl radical. The original acyl group is removed from the initially resulting 7-diacylamidocephem derivative. The free acid is obtained by removal of the protective group R'', which preferably represents an easily removable ester group. The said compounds are used as antibiotics.