ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF 3-METHYL-4-HALOGENISOXAZOL-5-YL-METHYLENOXYGUANIDIN ELLER FARMAKOLOGISK ACCEPTABLE SYREADDITIONSSALTE DERAF

Isoxazole derivatives of the general formula (I) and acid addition salts thereof (wherein R represents a C1-4 alkyl or a phenyl group, R2 denotes a halogen atom or a (C1-4 alkoxy)-carbonyl group, R1 represents a group of the formula -CH(NH2)-COOH, or a guanyl-thio, a bis- C1-4 alkoxycarbonyl-C1-4alkanoyl-amido- methyl, an amino-oxy, a carbamoylamino-oxy, a guanidino- oxy, a phthalimido-oxy group or a group of the general formula -NR3R4, wherein R3 stands for a hydrogen atom or a C1-4 alkyl, C3-6 cycloalkyl, omega -halogen-(C1-4 alkyl), di-(C1-4 alkyl)- amino-(C1-4 alkyl), 2,6- dihalogenbenzyl group or a p-amino- phenyl-sulfonyl group which latter may be N-substituted by a C1-4 alkanoyl group, and R4 stands for a hydrogen atom or a C1-4 alkyl group, or R3 and R4 together represent a 2,6- dihalogen-benzylidene group, or R3 and R4 form, together with the adjacent nitrogen atom a 6 membered heterocyclic ring which may optionally contain an oxygen as a further hetero atom, with the proviso that if R represents methyl and R1 stands for a guanyl-thio group, R2 may represent only chlorine), possess hypotensive, antiinflammatory and antipyretic activity.