TRIJODISOFTALSYREDERIVATER TIL ANVENDELSE SOM ROENTGENKONTRASTMIDLER SAMT RADIOLOGISKE PRAEPARATER INDEHOLDENDE DISSE

TRIJODISOFTALSYREDERIVATER TIL ANVENDELSE SOM ROENTGENKONTRASTMIDLER SAMT RADIOLOGISKE PRAEPARATER INDEHOLDENDE DISSE

Compounds of the formula: wherein R represents the group -CH2CH2OH or -CH2CHOHCH2OH, particularly in racemic or optically active form, are employed as active ingredients in X-ray contrast agents for intracerebral, but particularly for vascular use. The compounds are prepared by reacting 5-(N-acetami...

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Bibliographische Detailangaben
Hauptverfasser: HOLTERMANN, HUGO, NORDAL, VEGARD
Format: Patent
Sprache:dan
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Compounds of the formula: wherein R represents the group -CH2CH2OH or -CH2CHOHCH2OH, particularly in racemic or optically active form, are employed as active ingredients in X-ray contrast agents for intracerebral, but particularly for vascular use. The compounds are prepared by reacting 5-(N-acetamido)-2,4,6-triiodo-N,N'-bis-(2,3-dihydroxypropyl)isophthala mide or an O-acetyl derivative thereof with an appropriate hydroxyalkylating agent and subsequently, if necessary, hydrolysing any unwanted O-acetyl groups.