Process for preparing N-(2-amino-3,5-dibromobenzyl)-N- methylcyclohexylamine

Process for preparing N-(2-amino-3,5-dibromobenzyl)-N- methylcyclohexylamine

The preparation of N-(2-amino-3,5-dibromobenzyl)-N- methylcyclohexylamine, whose hydrochloride has the formula takes place by brominating 1,4-dihydro-2H-3,1-benzoxazin- 2-one with free bromine to give 6,8-dibromo-1,4-dihydro- 2H-3,1-benzoxazin-2-one, which is then reacted with N- methylcyclohexylami...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HERBERT PREIKSCHAT, BOERGE ALHEDE, NIELS GELTING
Format: Patent
Sprache:dan ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The preparation of N-(2-amino-3,5-dibromobenzyl)-N- methylcyclohexylamine, whose hydrochloride has the formula takes place by brominating 1,4-dihydro-2H-3,1-benzoxazin- 2-one with free bromine to give 6,8-dibromo-1,4-dihydro- 2H-3,1-benzoxazin-2-one, which is then reacted with N- methylcyclohexylamine to give bromohexyne [sic]. The reaction preferably takes place by heating in hexamethylphosphoramide at the boiling point of the latter.