Fremgangsmåde til overvågning og modulering af proteinfoldning

This invention relates to a new method for improving functional protein expression whereby the folding process is monitored by online measurement and, if required, the protein folding is influenced by adding folding promoting agents and/or co-expression of the periplasmic chaperone (Skp). In this re...

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Bibliographische Detailangaben
Hauptverfasser: STRITTMATTER, WOLFGANG, HORN, UWE, RIESENBERG, DIETER
Format: Patent
Sprache:dan
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Beschreibung
Zusammenfassung:This invention relates to a new method for improving functional protein expression whereby the folding process is monitored by online measurement and, if required, the protein folding is influenced by adding folding promoting agents and/or co-expression of the periplasmic chaperone (Skp). In this respect, the invention offers a technology to improve the yield of functionally expressed recombinant proteins.