Analogifremgangsmåde til fremstilling af 2-amino-3,5-dinitrothiophenforbindelser

Compound represented by the formula WHEREIN R1 represents lower alkyl, lower alkenyl, lower alkynyl, halo lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, lower alkylthio lower alkyl, lower alkylcarbonyl, halo lower alkylcarbonyl, lower alkanoyloxy lower alkyl, lower aroyloxy lower alkyl, pyridylcarbonyloxy lower alkyl, lower alkylaminocarbonyloxy lower alkyl or IN WHICH R4 and R5 each represent hydrogen or lower alkyl or R4 and R5 together with the nitrogen atom to which they are attached represent a 3-, 5-, 6- or 7-membered saturated heterocyclic ring which, in the case of a 5-, 6- or 7-membered ring, may contain a further nitrogen atom or an oxygen or sulphur atom and may be substituted by lower alkyl or hydroxy lower alkyl and n stands for 1, 2, 3 or 4, R2 represents hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy lower alkyl or hydroxy lower alkyl or R1 and R2 together with the nitrogen atom to which they are attached represent a 3-, 5-, 6- or 7-membered saturated heterocyclic ring which, in the case of a 5-, 6- or 7-membered ring, may contain a further nitorgen atom or an oxygen or sulphur atom and may be substituted by lower alkyl or hydroxy lower alkyl and R3 represents hydrogen or halogen or lower alkyl, provided that when R1 represents lower alkyl and R2 and R3 each represent hydrogen and the variable nitro group is present in the 5-position, then R1 represents lower alkyl containing 2 to 7 carbon atoms, AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS OF THOSE COMPOUNDS DESCRIBED HEREIN WHICH ARE BASIC AND THUS AMENABLE TO FORMING ACID ADDITION SALTS HAVING PROTOZOACIDAL, BACTERICIDAL, ANTHELMINTIC AND SCHISTOSOMICIDAL ACTIVITY ARE DISCLOSED.