L-N-N-PROPYLPIPECOLINSYRE-2,6-XYLIDID OG FREMGANGSMAADE TIL FREMSTILLING DERAF

The local anesthetic, L-N-n-propylpipecolic acid-2,6-xylidide of formula (I). This compound is prepared by chlorinating L-pipecolic acid to yield the acid chloride, namely L-pipecolic acid chloride. The acid chloride is then reacted with 2,6-xylidine to yield L-pipecolic acid-2,6-xylidide. The L-N-p...

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Bibliographische Detailangaben
Hauptverfasser:	BOVIN CHRISTER, THURESSON AF EKENSTAM BO
Format:	Patent
Sprache:	dan
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The local anesthetic, L-N-n-propylpipecolic acid-2,6-xylidide of formula (I). This compound is prepared by chlorinating L-pipecolic acid to yield the acid chloride, namely L-pipecolic acid chloride. The acid chloride is then reacted with 2,6-xylidine to yield L-pipecolic acid-2,6-xylidide. The L-N-pipecolic acid-2,6-xylidide is then propylated to yield the L-N-n-propylpipecolic acid-2,6-xylidide, which is a potent local anesthetic for mammals including man and is of relatively low toxicity.