DK130215C

1350878 Thieno-coumarins SHIONOGI & CO Ltd 24 May 1972 [31 May 1971] 24550/72 Heading C2C Novel compounds (I) where R 1 , R 2 and R 3 are H or alkyl and Y is H or one or two substituents (i.e. halogen, alkyl and/or alkoxy) are made by cyclizing compounds (II) to (V) in the presence of a mercapto group introducing agent (e.g. thiourea or an alkali metal sulphide or hydrosulphide) where appropriate (R 4 is H or alkyl such that R 1 is equivalent to -CH 2 R 4 , R 5 is H or acyl and X is halogen); (II) to (V) are themselves obtained by standard methods. Pharmaceutical preparations showing analgesic and antipyretic actions contain (I) as active ingredient; administration is, e.g. orally.