Vacciner mod HIV-infektion

A virus neutralizing level of antibodies to a primary HIV isolate is generated in a host by a prime-boost administration of antigents. The primary antigen is a DNA molecule encoding an envelop glycoprotein of a primary isolate of HIV-1 while the boosting antigen is either a non-infectious, non-repli...

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Bibliographische Detailangaben
Hauptverfasser: KLEIN, MICHEL, H, ROVINSKI, BENJAMIN, CAO, SHI-XIAN, PERSSON, ROY, TARTAGLIA, JAMES
Format: Patent
Sprache:dan
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Zusammenfassung:A virus neutralizing level of antibodies to a primary HIV isolate is generated in a host by a prime-boost administration of antigents. The primary antigen is a DNA molecule encoding an envelop glycoprotein of a primary isolate of HIV-1 while the boosting antigen is either a non-infectious, non-replicating HIV-like particle having the envelope glycoprotein of a primary isolate of HIV-1 or an attenuated viral vector expressing an envelope glycoprotein of a primary isolate of HIV-1.