FREMGANGSMÅDE TIL IN VITRO-FREMSTILLING AF TREDIMENSIONALT, VITALT BRUSK- ELLER KNOGLEVÆV

In vitro preparation of three-dimensional, living cartilage or bone tissue comprising culturing human or animal cartilage, bone or mesenchymal cells in vessels that have a hydrophobic surface and a tapering base, is new. In vitro preparation of three-dimensional, living cartilage or bone tissue comp...

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Bibliographische Detailangaben
Hauptverfasser:	ANDERER, URSULA, FRITSCH, KARL-GERD, LIBERA, JEANETTE, JOSIMOVIC-ALASEVIC, OLIVERA
Format:	Patent
Sprache:	dan
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	In vitro preparation of three-dimensional, living cartilage or bone tissue comprising culturing human or animal cartilage, bone or mesenchymal cells in vessels that have a hydrophobic surface and a tapering base, is new. In vitro preparation of three-dimensional, living cartilage or bone tissue comprises culturing human or animal cartilage, bone or mesenchymal cells in vessels that have a hydrophobic surface and a tapering base Culture is done until cell aggregates are formed, under stationary, submerged conditions. The culture contains at least 40% extracellular matrix (ECM) and has differentiated cells embedded in ECM. The aggregates include an outer region in which proliferation- and migration-competent cells are present. Independent claims are also included for the following: (a) production of cartilage and bone tissue; and (b) therapeutic composition containing the cartilage and bone tissue. - ACTIVITY : Antiarthritic; antirheumatic. No biological data provided. - MECHANISM OF ACTION : Cell replacement. No biological data provided.