4-pyrimidinyl-N-acyl-L-phenylanin

4-pyrimidinyl-N-acyl-L-phenylanin

Coumpounds of Formula (I) are disclosed, wherein R to R are as defined in specification and which are inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly are useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells expressin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SIDDURI, ACHYUTHARAO, TILLEY, JEFFERSON, WRIGHT
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Coumpounds of Formula (I) are disclosed, wherein R to R are as defined in specification and which are inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly are useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.