Analogifremgangsmåde til fremstilling af amino-halogen-benzylaminer eller syreadditionssalte heraf

1,154,547. Substituted benzylamines. DR. KARL THOMAE G.m.b.H. 6 Dec., 1966, No. 54637/66. Addition to 1,054,010. Heading C2C. Novel 2-amino-chlorobenzylamines (and organic or inorganic acid addition salts thereof) having pharmacological properties of the general formula in which Hal represents a chlorine atom in the 3- or 6-position, and R 1 and R 2 , which may be the same or different, represent straight or branched, saturated or unsaturated, aliphatic hydrocarbon groups, hydroxyalkyl, cycloalkyl, aryl, substituted aryl, aralkyl or substituted aralkyl groups, or R 1 and R 2 , together with the adjacent nitrogen atom represent a 5- to 7- membered saturated heterocyclic ring, which may be substituted by one or more lower alkyl groups and/or be interrupted by a further nitrogen atom, may be prepared by the reduction of either a chloro-2-nitro-benzylamine or a 2-amino-chloro-benzamide or by the interaction of a mono- or a di acylamino-chlorobenzyl halide with an amine of formula R 1 R 2 NH and subsequent deacylation. Pharmaceutical compositions having antipyretic, secretolytic and antitussive action contain as the active ingredient the above novel compounds; administration is orally, rectally or parenterally.