Hidtil ukendte spiroforbindelser med neuropeptid Y antagonistaktivitet
Spiro compounds of the general formula (I):whereinAr1 represents an optionally substituted aryl or heteroaryl;n represents 0 or 1;T, U, V and W each represent a nitrogen atom or an optionally substituted methine group, wherein at least two of which represent said methine group;X represents nitrogen;...
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| creator | KANATANI, AKIO BANYU PHARMACEUTICAL CO. LTD ISHIHARA, AKANE BANYU PHARMACEUTICAL CO., LTD ITOH, TAKAHIRO BANYU PHARMACEUTICAL CO., LTD FUKAMI, TAKEHIRO BANYU PHARMACEUTICAL CO., LTD ISHII, YASUYUKI BANYU PHARMACEUTICAL CO., LTD SAKAMOTO, TOSHIHIRO BANYU PHARMACEUTICAL CO., LTD HAGA, YUJI BANYU PHARMACEUTICAL CO., LTD TAKAHASHI, TOSHIYUKI BANYU PHARMACEUTICAL CO., LTD |
| description | Spiro compounds of the general formula (I):whereinAr1 represents an optionally substituted aryl or heteroaryl;n represents 0 or 1;T, U, V and W each represent a nitrogen atom or an optionally substituted methine group, wherein at least two of which represent said methine group;X represents nitrogen;Y represents an optionally substituted imino or oxygen atom, which exhibit neuropeptide Y receptor (NPY) antagonistic activities and are useful as agents for the treatment of various diseases related to NPY, for example, cardiovascular disorders, central nervous system disorders, metobolic diseases and the like. |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Hidtil ukendte spiroforbindelser med neuropeptid Y antagonistaktivitet |
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