Hidtil ukendte spiroforbindelser med neuropeptid Y antagonistaktivitet

Spiro compounds of the general formula (I):whereinAr1 represents an optionally substituted aryl or heteroaryl;n represents 0 or 1;T, U, V and W each represent a nitrogen atom or an optionally substituted methine group, wherein at least two of which represent said methine group;X represents nitrogen;...

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Hauptverfasser:	KANATANI, AKIO BANYU PHARMACEUTICAL CO. LTD, ISHIHARA, AKANE BANYU PHARMACEUTICAL CO., LTD, ITOH, TAKAHIRO BANYU PHARMACEUTICAL CO., LTD, FUKAMI, TAKEHIRO BANYU PHARMACEUTICAL CO., LTD, ISHII, YASUYUKI BANYU PHARMACEUTICAL CO., LTD, SAKAMOTO, TOSHIHIRO BANYU PHARMACEUTICAL CO., LTD, HAGA, YUJI BANYU PHARMACEUTICAL CO., LTD, TAKAHASHI, TOSHIYUKI BANYU PHARMACEUTICAL CO., LTD
Format:	Patent
Sprache:	dan
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Spiro compounds of the general formula (I):whereinAr1 represents an optionally substituted aryl or heteroaryl;n represents 0 or 1;T, U, V and W each represent a nitrogen atom or an optionally substituted methine group, wherein at least two of which represent said methine group;X represents nitrogen;Y represents an optionally substituted imino or oxygen atom, which exhibit neuropeptide Y receptor (NPY) antagonistic activities and are useful as agents for the treatment of various diseases related to NPY, for example, cardiovascular disorders, central nervous system disorders, metobolic diseases and the like.