Fremstilling af quinolinsubstituerede carbonat- og carbamatderivater

The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: NICHOLS, PAUL J, PLATA, DANIEL, J, CONDON, STEPHEN, DEMATTEI, JOHN, J, MANNA, SUKUMAR, CHANG, SOU-JEN, KING, STEVEN, A, PATEL, HEMANT, H, ALLEN, MICHAEL, S, KOLACZKOWSKI, LAWRENCE, STONER, ERIC, J, PATEL, SUBHASH, R, WITTENBERGER, STEVEN, J, PREMCHANDRAN, RAMIYA, H, TIEN, JIEN-HEH, J
Format: Patent
Sprache:dan
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -CH=CHCH 2 OC(O)-X-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)