FREMGANGSMAADE TIL FREMSTILLING AF 3BETA-HYDROXYMETHYL-4ALFA-HYDROXY-8BETA-ALKOXY-2,9-DIOXATRICYCLO(4,3,1,03,7)-DECANER

FREMGANGSMAADE TIL FREMSTILLING AF 3BETA-HYDROXYMETHYL-4ALFA-HYDROXY-8BETA-ALKOXY-2,9-DIOXATRICYCLO(4,3,1,03,7)-DECANER

Novel and highly effective sleep inducing 3 beta -hydroxy methyl-4 alpha -hydroxy-8 beta -alkoxy-2,9-dioxa tricyclo [4,3,1,03,7] decane compounds of the following Formula: in which R1 indicates an alkoxy group and preferably a lower alkoxy group, such as the methoxy group, the ethoxy group, or the n...

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Bibliographische Detailangaben
Hauptverfasser: THIES PETER WILLIBRORD, DAVID SAMUEL
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Novel and highly effective sleep inducing 3 beta -hydroxy methyl-4 alpha -hydroxy-8 beta -alkoxy-2,9-dioxa tricyclo [4,3,1,03,7] decane compounds of the following Formula: in which R1 indicates an alkoxy group and preferably a lower alkoxy group, such as the methoxy group, the ethoxy group, or the n-butoxy group, while R2 indicates the 10-methylene group or the 10 beta -methyl group, are produced from didrovaltratum, i.e., 1-isovaleroxy-4-isovaleroxy methyl-7-acetoxy-spiro-oxirano-1,9-dihydrocyclopenta(c)pyrane or from extracts of plants of the genus Valerianaceae which contain about 70% of didrovaltratum. The novel compounds have a surprisingly low toxicity.