(1R, 2S,4R)-(-)-2-[(N,N-dimethylamino)-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptan af høj renhedsgrad og farmaceutisk acceptable syretilsætningssalte deraf, fremgangsmåde til fremstilling

(1R, 2S,4R)-(-)-2-[(N,N-dimethylamino)-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptan af høj renhedsgrad og farmaceutisk acceptable syretilsætningssalte deraf, fremgangsmåde til fremstilling

The invention relates to high purity (1R,2S,4R)-(-)-2-[(2'-{N,N-dimethylamino}-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptane and pharmaceutically acceptable acid addition salts thereof containing not more than 0.2% of (1R,3S,4R)-3-[(2'-{N,N-dimethylamino}-ethyl)]-1,7,7-tri-[...

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Hauptverfasser: PORCS-MAKKAY, MARTA, SIMIG, GYULA, NEMETH, NORBERT, KRASZNAI, GYOERGY, NAGY, KALMAN, BUDAI, ZOLTAN, LUKACS, GYULA, MEZEI, TIBOR, SZABO, TIBOR, SZULAGYI, JANOS, VERECZKEY, GYOERGYI DONATH
Format: Patent
Sprache:dan
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Zusammenfassung:The invention relates to high purity (1R,2S,4R)-(-)-2-[(2'-{N,N-dimethylamino}-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptane and pharmaceutically acceptable acid addition salts thereof containing not more than 0.2% of (1R,3S,4R)-3-[(2'-{N,N-dimethylamino}-ethyl)]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptane-2-one and/or of a pharmaceutically acceptable acid addition salt thereof.Furthermore the invention is concerned with a process for the preparation of these compounds.Moreover the invention relates to medicaments containing 1 or more of these compounds and their use.