FREMGANGSMAADE TIL FREMSTILLING AF N-(6- ( (ACYLAMINOACYLAMINO ELLER AMINOACYLAMINO)PHENYL)-1,2-DIHYDRO-2-OXONICOTINYL) CEPHALOSPORINFORBINDELSER

FREMGANGSMAADE TIL FREMSTILLING AF N-(6- ( (ACYLAMINOACYLAMINO ELLER AMINOACYLAMINO)PHENYL)-1,2-DIHYDRO-2-OXONICOTINYL) CEPHALOSPORINFORBINDELSER

N-[6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinyl] cephalosporin compounds having the formula: with broad spectrum antibacterial utility are provided, which can be produced by (a) reacting the free amino acid of the appropriate cephalosporin or the acid salt or silylated...

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Bibliographische Detailangaben
Hauptverfasser: HASKELL T H, MICH T F, SCHWEISS D, CULBERTSON T P
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:N-[6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinyl] cephalosporin compounds having the formula: with broad spectrum antibacterial utility are provided, which can be produced by (a) reacting the free amino acid of the appropriate cephalosporin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinic acid, or (b) reacting the free amino acid 7-aminocephalosporanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing the novel compounds and methods for treating infections using such compositions are also disclosed.