Fremgangsmåde til fremstilling af N-(4-flourphenyl)-N-(11-methyl-ethyl)-2-[5-trifluormethyl)-1,3,4-thiadiazol-2-yl)-oxy]-acetamid ved anvendelse af et aprotisk, aromatisk oplösningsmiddel

New preparation of N-(4-fluorophenyl)-N-(1-methylethyl)-2-((5-trifluoromethyl)-1,3,4-thiadiazol-2-yl)oxy) acetamide (I) uses an aprotic, aromatic solvent. Preparation of N-(4-fluorophenyl)-N-(1-methylethyl)-2-((5-trifluoromethyl)-1,3,4-thiadiazol-2-yl)oxy) acetamide (fluthiamide) (I) comprises: (a)...

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Hauptverfasser:	WASLESKI, DANIEL M, PRASAD, VIDYANATHA A, JELICH, KLAUS DR, NEWALLIS, PETER E, APPLEGATE, JACQUELINE M. DR
Format:	Patent
Sprache:	dan
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING
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Zusammenfassung:	New preparation of N-(4-fluorophenyl)-N-(1-methylethyl)-2-((5-trifluoromethyl)-1,3,4-thiadiazol-2-yl)oxy) acetamide (I) uses an aprotic, aromatic solvent. Preparation of N-(4-fluorophenyl)-N-(1-methylethyl)-2-((5-trifluoromethyl)-1,3,4-thiadiazol-2-yl)oxy) acetamide (fluthiamide) (I) comprises: (a) reacting 2-(methylsulphonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole with N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl) acetamide in the presence of an aqueous alkali and an aprotic, aromatic solvent to form and aqueous phase and an organic phase; (b) acidifying the mixture by addition of a mineral acid; (c) separating the phases; and (d) recovering (I) from the organic phase.