Substituerede pyrazolylbenzensulfonamider og anvendelse deraf som cyclooxygenase II-inhibitorer

The present invention is related to substituted pyrazolyl benzenesulfonamides of the Formula I wherein R is selected from hydrido, C1-C10-alkyl, C1-C6-haloalkyl, C1-C6-alkoxycarbonyl, cyano, carboxyl, C1-C6-cyanoalkyl, aminocarbonyl, C1-C6-alkylaminocarbonyl, C3-C7-cycloalkylaminocarbonyl, arylaminocarbonyl, C1-C6-carboxyalkylaminocarbonyl, aryl-C1-C6-alkoxycarbonyl-C1-C10-alkylaminocarbonyl, C1-C6-aminocarbonylalkyl, C1-C6-carboxyalkyl, C1-C6-alkoxycarbonylcyano-C2-C6-alkenyl and C1-C6-hydroxyalkyl; wherein R is selected from hydrido, C1-C10-alkyl, cyano, C1-C6-hydroxyalkyl, C3-C7-cycloalkyl, C1-C6-alkylsulfonyl, and halo; and wherein R is selected from optionally substituted C3-C10-cycloalkyl, C3-C10- cycloalkenyl and heterocyclic; provided R and R are not both hydrido, further provided that R is not triazolyl when R is methyl; and further provided that R is not substituted thienyl when R is trifluoromethyl; or a pharmaceutically-acceptable salt thereof. The invention is also related to pharmaceutical compositions containing such compounds.