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The invention concerns a method of comparative high-throughput screening of pharmacologically active substances. In one process step the substances are deposited on test cells that contain one or more biological target molecules, the cells having an identical biological base composition and differin...

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Hauptverfasser:	WEYER-CZERNILOFSKY, ULRIKE, LOEBER, GERHARD, VON RUEDEN, THOMAS, TONTSCH, ULRIKE, SCHNITZER, RENATE, WICHE-CASTANON, MARIA, JOSEFA, CZERNILOFSKY, ARMIN, PETER, METZ, THOMAS, STRATOWA, CHRISTIAN, HIMMLER, ADOLF, SPEVAK, WALTER
Format:	Patent
Sprache:	dan
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention concerns a method of comparative high-throughput screening of pharmacologically active substances. In one process step the substances are deposited on test cells that contain one or more biological target molecules, the cells having an identical biological base composition and differing in their target molecules, and/or are deposited on cells having a different biological base composition and identical target molecules. The effect of the substance on the activity of the target molecules is measured using a detection system linked to the activation of the target molecule and is compared directly with the effect on other molecules.