Interaktion af cyclin D1 og estrogenreceptor og anvendelse deraf i assays

Interaktion af cyclin D1 og estrogenreceptor og anvendelse deraf i assays

PCT No. PCT/EP97/01888 Sec. 371 Date Apr. 6, 1999 Sec. 102(e) Date Apr. 6, 1999 PCT Filed Apr. 16, 1997 PCT Pub. No. WO97/40378 PCT Pub. Date Oct. 30, 1997The present invention relates to the finding that cyclin D1 interacts with estrogen receptor to provide activation of estrogen responsive genes....

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Bibliographische Detailangaben
Hauptverfasser: MICHALIDES, ROB, J., A., M, BERNARDS, RENE, ZWIJSEN, RENATE, M., L
Format: Patent
Sprache:dan
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Zusammenfassung:PCT No. PCT/EP97/01888 Sec. 371 Date Apr. 6, 1999 Sec. 102(e) Date Apr. 6, 1999 PCT Filed Apr. 16, 1997 PCT Pub. No. WO97/40378 PCT Pub. Date Oct. 30, 1997The present invention relates to the finding that cyclin D1 interacts with estrogen receptor to provide activation of estrogen responsive genes. The present invention provides in vitro and in vivo assays to measure the interaction. The in vivo assays may be conducted in cells which grow in response to estrogen, particularly breast tumour cells.