Fremgangsmåde til fremstilling af chromatografisk ren cyclosporin ved brug af en eluent, der i alt væsentligt er sammensat af carbondioxid under høj tryk

Fremgangsmåde til fremstilling af chromatografisk ren cyclosporin ved brug af en eluent, der i alt væsentligt er sammensat af carbondioxid under høj tryk

PCT No. PCT/FI96/00120 Sec. 371 Date Nov. 12, 1997 Sec. 102(e) Date Nov. 12, 1997 PCT Filed Mar. 1, 1996 PCT Pub. No. WO96/27607 PCT Pub. Date Sep. 12, 1996A process is provided for the preparation of pure cyclosporin which is purified chromatographically from a mixture of different cyclosporin form...

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Hauptverfasser: LUNDELL, JUHANI, SUORTTI, TAPANI, HASE, ANNELI, RUOHONEN, JARKKO, ALKIO, MARTTI, AALTONEN, OLLI
Format: Patent
Sprache:dan
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:PCT No. PCT/FI96/00120 Sec. 371 Date Nov. 12, 1997 Sec. 102(e) Date Nov. 12, 1997 PCT Filed Mar. 1, 1996 PCT Pub. No. WO96/27607 PCT Pub. Date Sep. 12, 1996A process is provided for the preparation of pure cyclosporin which is purified chromatographically from a mixture of different cyclosporin forms and other substances prepared by fermentation. The process comprises feeding a mixture containing a desired form of cyclosporin with an eluent consisting of high pressure carbon dioxide and an adjuvant, into a chromatography column being packed with particles prepared of silica, and recovering from the eluent flow coming out of the chromatography column a fraction which contains the desired cyclosporin form in adequately pure form.