Huperzinderivater, deres fremstilling og anvendelse

Huperzinderivater, deres fremstilling og anvendelse

The present invention relates to novel huperzine A derivatives of formula (II), wherein Y is or R'' and Y together form =CH; R is (C1-C5) alkyl, wherein n is 0 or 1, X is H, (C1-C5) alkyl; (C1-C5) alkyloxy; nitro, halogen, carboxy, alkyloxycarbonyl, hydroxymethyl, hydroxy, amino substitute...

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Bibliographische Detailangaben
Hauptverfasser: ZHU, CHENG, LIN, JINLAI, WAKANATSU, TAKESHI, SHEN, JINGKANG, TANAKA, KAZUHIRO, TANG, XICAN, WU, GUANSONG, JIANG, SHANHAO, NISHIMURA, HIROAKI, ZHU, DAYUAN, YAMAGUCHI, TAKUJI
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to novel huperzine A derivatives of formula (II), wherein Y is or R'' and Y together form =CH; R is (C1-C5) alkyl, wherein n is 0 or 1, X is H, (C1-C5) alkyl; (C1-C5) alkyloxy; nitro, halogen, carboxy, alkyloxycarbonyl, hydroxymethyl, hydroxy, amino substituted by bis-(C1-C5) alkyl; -(CH2)mCOOZ, wherein m=0-5, Z is H or (C1-C5) alkyl; -CH=CH-G, wherein G is phenyl, furanyl, carboxy, alkyloxycarbonyl; and dihydro- or tetrahydro-pyridyl substituted by (C1-C5) alkyl at the nitrogen atom; R' is H, (C1-C5) alkyl, pyridoyl, benzoyl substituted by (C1-C5) alkyloxy; R'' is H or (C1-C5) alkyl; processes for their use as acetylcholinesterase inhibitor.