Fremgangsmåde til fremstilling af enantiomerer fra O-demethyltramadol

Preparation of the enantiomers of O-demethyltramadol (II) comprises: (a) converting racemic tramadol (I) salt to its base form; (b) separating the (-)-(I)-enantiomer by precipitation using L-(+)-tartaric acid; (d) reaction of the (-)-(I)-enantiomer with diisobutyl aluminium hydride (DIBAL) to give (...

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Bibliographische Detailangaben
Hauptverfasser:	STRASSBURGER, WOLFGANG, -DR, WINTER, WERNER, -DR, FRIDERICH, ELMAR, JANSEN, PETER, BUSCHMANN, HELMUT, GRAUDUMS, IVARS
Format:	Patent
Sprache:	dan
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Preparation of the enantiomers of O-demethyltramadol (II) comprises: (a) converting racemic tramadol (I) salt to its base form; (b) separating the (-)-(I)-enantiomer by precipitation using L-(+)-tartaric acid; (d) reaction of the (-)-(I)-enantiomer with diisobutyl aluminium hydride (DIBAL) to give (-)-(II); (e) separation of the (+)-(I)-enantiomer as a free base from the mother liquor obtained in step (b); and (f) reaction of the (+)-(I) enantiomer with DIBAL to give (+)-(II).