Hidtil ukendte benzimidazolderivater med CGMP-phosphodiesteraseinhiberende aktivitet

Hidtil ukendte benzimidazolderivater med CGMP-phosphodiesteraseinhiberende aktivitet

PCT No. PCT/JP96/01841 Sec. 371 Date Mar. 6, 1997 Sec. 102(e) Date Mar. 6, 1997 PCT Filed Jul. 3, 1996 PCT Pub. No. WO97/03070 PCT Pub. Date Jan. 30, 1997The present invention provides novel benzimidazole derivatives or salts thereof represented by the general formula, wherein R1 is a hydrogen atom...

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Hauptverfasser: YUKAWA, HIROTAKA, KOGA, NOBUYUKI, NISHI, TAKAO, YOSHINAGA, SHINJI, SAITO, MASAHIRO, NAGATANI, TAKESHI, SATO, SEIJI
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:PCT No. PCT/JP96/01841 Sec. 371 Date Mar. 6, 1997 Sec. 102(e) Date Mar. 6, 1997 PCT Filed Jul. 3, 1996 PCT Pub. No. WO97/03070 PCT Pub. Date Jan. 30, 1997The present invention provides novel benzimidazole derivatives or salts thereof represented by the general formula, wherein R1 is a hydrogen atom or a halogen atom; R2 is a phenyl-lower alkyl group; R3 is a heterocyclic group selected from the group consisting of an indolyl group, indolinyl group, 1H-indazolyl group, 2(1H)-quinolinonyl group, 3,4-dihydro-2(1H)-quinolinonyl group and 1,4-benzoxazinyl group; A is a lower alkylene group; n is 0 or 1. The benzimidazole derivatives or salts of the present invention are effective agents for treating various arteriosclerotic diseases.