Hæmmere af metozoan-parasit-proteaser

PCT No. PCT/US93/08708 Sec. 371 Date Mar. 28, 1995 Sec. 102(e) Date Mar. 28, 1995 PCT Filed Sep. 13, 1993 PCT Pub. No. WO94/06280 PCT Pub. Date Mar. 31, 1994Compositions and methods for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite p...

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Hauptverfasser:	COHEN, FRED EHRENKRANZ, RING, CHRISTINE SUN YOUNG, KENYON, GEORGE LOMMEL, MCKERROW, JAMES HOBSON, ROSENTHAL, PHILIP JON, LI, ZHE
Format:	Patent
Sprache:	dan
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	PCT No. PCT/US93/08708 Sec. 371 Date Mar. 28, 1995 Sec. 102(e) Date Mar. 28, 1995 PCT Filed Sep. 13, 1993 PCT Pub. No. WO94/06280 PCT Pub. Date Mar. 31, 1994Compositions and methods for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease. The compositions comprise at least one metazoan protease inhibitor which binds to the S2 subsite and at least one of the S1 and S1' subsites of the metazoan parasite protease. The methods comprise administration to a patient infected with a metazoan parasite of at least one metazoan protease inhibitor in an amount effective to inhibit the protease of the metazoan parasite, thereby killing the parasite.