Fremgangsmåder og mellemprodukter til fremstilling af 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chlor-1,3-dihydro-indol-2-on

Fremgangsmåder og mellemprodukter til fremstilling af 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chlor-1,3-dihydro-indol-2-on

A process for preparing the compound of the formula I which comprises treating a compound of the formula II wherein R2 is hydrogen, CN or CO2R1 and R1 is hydrogen or (C1-C6)alkyl with a reducing agent with the proviso that when R2 is CN or CO2R1 and R1 is (C1-C6)alkyl the product of the reduction is...

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Bibliographische Detailangaben
1. Verfasser: URBAN, FRANK, JOHN
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A process for preparing the compound of the formula I which comprises treating a compound of the formula II wherein R2 is hydrogen, CN or CO2R1 and R1 is hydrogen or (C1-C6)alkyl with a reducing agent with the proviso that when R2 is CN or CO2R1 and R1 is (C1-C6)alkyl the product of the reduction is heated with an acid. Compounds of formula II wherein R2 is CN or CO2R1 and R1 is (C1-C6)alkyl or R2 is hydrogen and R1 is (C1-C6)alkyl or hydrogen. The compound of formula VII R1 is (C1-C6)alkyl. The compound of formula III. The compound of formula I is useful in the treatment of psychotic disorders.