Fremgangsmåde til fremstilling af 6-fluor-2-halogenoquinoliner

Fremgangsmåde til fremstilling af 6-fluor-2-halogenoquinoliner

PCT No. PCT/US94/11832 Sec. 371 Date Jun. 7, 1995 Sec. 102(e) Date Jun. 7, 1995 PCT Filed Oct. 20, 1994 PCT Pub. No. WO94/24113 PCT Pub. Date Oct. 27, 1994Method of preparation of 6-fluoro-2-halogen quinoline of general formula (I) wherein R is a hydrogen atom or an alkyl radical and Hal and Hal...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LEON, PATRICK, GARCIA, HERVE, JACQUOT, ROLAND
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:PCT No. PCT/US94/11832 Sec. 371 Date Jun. 7, 1995 Sec. 102(e) Date Jun. 7, 1995 PCT Filed Oct. 20, 1994 PCT Pub. No. WO94/24113 PCT Pub. Date Oct. 27, 1994Method of preparation of 6-fluoro-2-halogen quinoline of general formula (I) wherein R is a hydrogen atom or an alkyl radical and Hal and Hal' are identical or different halogen atoms. The invention is characterized in that a halogenating agent is made to act on hydroxy-1 quinoline of general formula (II) wherein Hal is defined as above and R1 is defined as R excepting a hydrogen atom, the acid function being optionally released if a 6-fluoro-2-halogen quinoline is to be obtained for which R is a hydrogen atom.